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Microscopic study of bovine serum albumin adsorption on zinc oxide (0001) surface
- 1.0541730 - FZÚ 2022 RIV DE eng J - Journal Article
Rezek, B. - Hematian, H. - Jíra, J. - Rutherford, D. - Kuliček, J. - Ukraintsev, Egor - Remeš, Zdeněk
Microscopic study of bovine serum albumin adsorption on zinc oxide (0001) surface.
Physica Status Solidi A. Roč. 218, č. 6 (2021), č. článku 2000558. ISSN 1862-6300. E-ISSN 1862-6319
R&D Projects: GA ČR GC19-02858J; GA MŠMT LM2018110
Institutional support: RVO:68378271
Keywords : adhesions * albumin * atomic force microscopy * force fields * zinc oxide
OECD category: Nano-materials (production and properties)
Impact factor: 2.170, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/pssa.202000558
Properties and functions of various ZnO materials are intensively investigated in biological systems for diagnostics, therapy, health risks assessment as well as bactericidal and decontamination purposes. Herein, the interface between ZnO and biological environment is studied by characterizing adsorption of bovine serum albumin (BSA) and fetal bovine serum (FBS) using atomic force microscopy with CF4-treated tips. Similar molecular morphologies (thickness around 2 nm) yet different binding forces to ZnO (10-25 nN) are observed. These observations are corroborated by atomic scale simulations of BSA on (0001) ZnO surface using force-field method and showing rearrangements of Zn surface atoms. Such binding may have an impact also on other properties of ZnO-BSA complex.
Permanent Link: http://hdl.handle.net/11104/0319262
Number of the records: 1