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DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome
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SYSNO ASEP 0539304 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome Author(s) Tomášová, Kristýna (UEM-P)
Čumová, Andrea (UEM-P)
Šeborová, K. (CZ)
Horák, Josef (UEM-P) ORCID
Koucká, K. (CZ)
Vodičková, Ludmila (UEM-P) RID
Václavíková, R. (CZ)
Vodička, Pavel (UEM-P) RIDArticle number 1713 Source Title Cancers (Basel). - : MDPI
Roč. 12, č. 7 (2020)Number of pages 37 s. Language eng - English Country CH - Switzerland Keywords ovarian cancer ; DNA repair ; carcinogenesis Subject RIV EB - Genetics ; Molecular Biology OECD category Human genetics R&D Projects GA19-10543S GA ČR - Czech Science Foundation (CSF) NV18-03-00199 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000556366400001 EID SCOPUS 85086923920 DOI 10.3390/cancers12071713 Annotation There is ample evidence for the essential involvement of DNA repair and DNA damage response in the onset of solid malignancies, including ovarian cancer. Indeed, high-penetrance germline mutations in DNA repair genes are important players in familial cancers:BRCA1,BRCA2mutations or mismatch repair, and polymerase deficiency in colorectal, breast, and ovarian cancers. Recently, some molecular hallmarks (e.g.,TP53,KRAS,BRAF,RAD51C/DorPTENmutations) of ovarian carcinomas were identified. The manuscript overviews the role of DNA repair machinery in ovarian cancer, its risk, prognosis, and therapy outcome. We have attempted to expose molecular hallmarks of ovarian cancer with a focus on DNA repair system and scrutinized genetic, epigenetic, functional, and protein alterations in individual DNA repair pathways (homologous recombination, non-homologous end-joining, DNA mismatch repair, base- and nucleotide-excision repair, and direct repair). We suggest that lack of knowledge particularly in non-homologous end joining repair pathway and the interplay between DNA repair pathways needs to be confronted. The most important genes of the DNA repair system are emphasized and their targeting in ovarian cancer will deserve further attention. The function of those genes, as well as the functional status of the entire DNA repair pathways, should be investigated in detail in the near future. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2021 Electronic address https://www.mdpi.com/2072-6694/12/7/1713
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