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DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome

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    SYSNO ASEP0539304
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleDNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome
    Author(s) Tomášová, Kristýna (UEM-P)
    Čumová, Andrea (UEM-P)
    Šeborová, K. (CZ)
    Horák, Josef (UEM-P) ORCID
    Koucká, K. (CZ)
    Vodičková, Ludmila (UEM-P) RID
    Václavíková, R. (CZ)
    Vodička, Pavel (UEM-P) RID
    Article number1713
    Source TitleCancers (Basel). - : MDPI
    Roč. 12, č. 7 (2020)
    Number of pages37 s.
    Languageeng - English
    CountryCH - Switzerland
    Keywordsovarian cancer ; DNA repair ; carcinogenesis
    Subject RIVEB - Genetics ; Molecular Biology
    OECD categoryHuman genetics
    R&D ProjectsGA19-10543S GA ČR - Czech Science Foundation (CSF)
    NV18-03-00199 GA MZd - Ministry of Health (MZ)
    Method of publishingOpen access
    Institutional supportUEM-P - RVO:68378041
    UT WOS000556366400001
    EID SCOPUS85086923920
    DOI10.3390/cancers12071713
    AnnotationThere is ample evidence for the essential involvement of DNA repair and DNA damage response in the onset of solid malignancies, including ovarian cancer. Indeed, high-penetrance germline mutations in DNA repair genes are important players in familial cancers:BRCA1,BRCA2mutations or mismatch repair, and polymerase deficiency in colorectal, breast, and ovarian cancers. Recently, some molecular hallmarks (e.g.,TP53,KRAS,BRAF,RAD51C/DorPTENmutations) of ovarian carcinomas were identified. The manuscript overviews the role of DNA repair machinery in ovarian cancer, its risk, prognosis, and therapy outcome. We have attempted to expose molecular hallmarks of ovarian cancer with a focus on DNA repair system and scrutinized genetic, epigenetic, functional, and protein alterations in individual DNA repair pathways (homologous recombination, non-homologous end-joining, DNA mismatch repair, base- and nucleotide-excision repair, and direct repair). We suggest that lack of knowledge particularly in non-homologous end joining repair pathway and the interplay between DNA repair pathways needs to be confronted. The most important genes of the DNA repair system are emphasized and their targeting in ovarian cancer will deserve further attention. The function of those genes, as well as the functional status of the entire DNA repair pathways, should be investigated in detail in the near future.
    WorkplaceInstitute of Experimental Medicine
    ContactLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Year of Publishing2021
    Electronic addresshttps://www.mdpi.com/2072-6694/12/7/1713
Number of the records: 1  

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