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Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
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SYSNO ASEP 0538457 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition Author(s) Kavková, M. (CZ)
Šulcová, Marie (UZFG-Y) ORCID
Dumková, J. (CZ)
Zahradníček, Oldřich (UJF-V) ORCID, SAI
Kaiser, J. (CZ)
Tucker, A. S. (GB)
Zikmund, T. (CZ)
Buchtová, Marcela (UZFG-Y) RID, ORCIDArticle number 22040 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 10, č. 1 (2020)Number of pages 16 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords teeth ; dental development Subject RIV EB - Genetics ; Molecular Biology OECD category Developmental biology Subject RIV - cooperation Nuclear Physics Institute - Other Medical Disciplines R&D Projects GA17-14886S GA ČR - Czech Science Foundation (CSF) LQ1601 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UZFG-Y - RVO:67985904 ; UJF-V - RVO:61389005 UT WOS 000603657800006 EID SCOPUS 85097609795 DOI 10.1038/s41598-020-78939-2 Annotation Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2021 Electronic address https://www.nature.com/articles/s41598-020-78939-2
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