Number of the records: 1
Left ventricular function and remodelling in rats exposed stepwise up to extreme chronic intermittent hypoxia
- 1.
SYSNO ASEP 0534241 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Left ventricular function and remodelling in rats exposed stepwise up to extreme chronic intermittent hypoxia Author(s) Papoušek, František (FGU-C)
Sedmera, David (FGU-C) RID, ORCID, SAI
Neckář, Jan (FGU-C) RID, ORCID
Ošťádal, Bohuslav (FGU-C) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAIArticle number 103526 Source Title Respiratory Physiology & Neurobiology. - : Elsevier - ISSN 1569-9048
Roč. 282, Nov (2020)Number of pages 6 s. Language eng - English Country NL - Netherlands Keywords chronic hypoxia ; extreme altitude ; heart function ; myocardial remodelling Subject RIV ED - Physiology OECD category Physiology (including cytology) R&D Projects GJ19-04790Y GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000579408900011 EID SCOPUS 85089702185 DOI 10.1016/j.resp.2020.103526 Annotation The main aim was to find out whether long-lasting stepwise exposure to extreme hypoxia affects left ventricular (LV) geometry and systolic function. Adult male rats were exposed to intermittent hypobaric hypoxia (8 h/day) with increasing altitude in steps of 1000 m every 3 weeks up to 8000 m. While the LV cavity diastolic diameter did not change over the whole range of hypoxia, the wall thickness increased significantly at the altitude of 8000 m. LV fractional shortening ranged between 48.1 % and 50.1 % and remained unaffected even at the most severe hypoxia. At the end of experiment, haematocrit reached 83 %, mean systemic arterial pressure 120 % and relative LV weight 154 % of normoxic values while RV systolic pressure and relative RV weight doubled. Myocyte hypertrophy and myocardial fibrosis were more pronounced in RV than in LV. In conclusion, LV systolic function was preserved after chronic stepwise exposure of rats to extreme intermittent hypoxia despite moderate concentric hypertrophy and myocardial remodelling. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://doi.org/10.1016/j.resp.2020.103526
Number of the records: 1