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Role of Mitochondrial Glycerol-3-Phosphate Dehydrogenase in Metabolic Adaptations of Prostate Cancer
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SYSNO ASEP 0532976 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Role of Mitochondrial Glycerol-3-Phosphate Dehydrogenase in Metabolic Adaptations of Prostate Cancer Author(s) Pecinová, Alena (FGU-C) RID, ORCID, SAI
Alán, Lukáš (FGU-C) RID, ORCID
Brázdová, Andrea (FGU-C) ORCID, RID, SAI
Vrbacký, Marek (FGU-C) RID, ORCID
Pecina, Petr (FGU-C) RID, ORCID
Drahota, Zdeněk (FGU-C) RID, ORCID
Houštěk, Josef (FGU-C) RID, ORCID
Mráček, Tomáš (FGU-C) RID, ORCIDArticle number 1764 Source Title Cells. - : MDPI
Roč. 9, č. 8 (2020)Number of pages 16 s. Language eng - English Country CH - Switzerland Keywords GPD2 gene ; mitochondrial glycerol-3-phosphate dehydrogenase (EC:1.1.5.3) ; prostate cancer ; metabolic adaptation Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA16-12726S GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000567281600001 EID SCOPUS 85088811124 DOI 10.3390/cells9081764 Annotation Prostate cancer is one of the most prominent cancers diagnosed in males. Contrasting with other cancer types, glucose utilization is not increased in prostate carcinoma cells as they employ different metabolic adaptations involving mitochondria as a source of energy and intermediates required for rapid cell growth. In this regard, prostate cancer cells were associated with higher activity of mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), the key rate limiting component of the glycerophosphate shuttle, which connects mitochondrial and cytosolic processes and plays significant role in cellular bioenergetics. Our research focused on the role of mGPDH biogenesis and regulation in prostate cancer compared to healthy cells. We show that the 42 amino acid presequence is cleaved from N-terminus during mGPDH biogenesis. Only the processed form is part of the mGPDH dimer that is the prominent functional enzyme entity. We demonstrate that mGPDH overexpression enhances the wound healing ability in prostate cancer cells. As mGPDH is at the crossroad of glycolysis, lipogenesis and oxidative metabolism, regulation of its activity by intramitochondrial processing might represent rapid means of cellular metabolic adaptations. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://www.mdpi.com/2073-4409/9/8/1764
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