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Monocytes undergo multi-step differentiation in mice during oral infection by Toxoplasma gondii

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    0523095 - BTÚ 2020 RIV GB eng J - Journal Article
    Detavernier, C. - Azouz, A. - Shehade, H. - Splittgerber, M. - Van Maele, L. - Nguyen, M. - Thomas, S. - Achouri, Y. - Švec, David - Calonne, E. - Fuks, F. - Oldenhove, G. - Goriely, S.
    Monocytes undergo multi-step differentiation in mice during oral infection by Toxoplasma gondii.
    Communications Biology. Roč. 2, č. 1 (2019), č. článku 472. E-ISSN 2399-3642
    R&D Projects: GA ČR(CZ) GJ18-24753Y; GA MŠMT(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : dendritic cells * inflammatory monocytes * activation * reveals * macrophages * expression
    OECD category: Other biological topics
    Impact factor: 4.165, year: 2019
    Method of publishing: Open access
    https://www.nature.com/articles/s42003-019-0718-6.pdf

    Monocytes play a major role in the defense against pathogens. They are rapidly mobilized to inflamed sites where they exert both proinflammatory and regulatory effector functions. It is still poorly understood how this dynamic and exceptionally plastic system is controlled at the molecular level. Herein, we evaluated the differentiation process that occurs in Ly6C(hi) monocytes during oral infection by Toxoplasma gondii. Flow cytometry and single-cell analysis revealed distinct activation status and gene expression profiles in the bone marrow, the spleen and the lamina propria of infected mice. We provide further evidence that acquisition of effector functions, such as the capacity to produce interleukin-27, is accompanied by distinct waves of epigenetic programming, highlighting a role for STAT1/IRF1 in the bone marrow and AP-1/NF-kappa B in the periphery. This work broadens our understanding of the molecular events that occur in vivo during monocyte differentiation in response to inflammatory cues.
    Permanent Link: http://hdl.handle.net/11104/0307500

     
     
Number of the records: 1  

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