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Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure
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SYSNO ASEP 0505666 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure Author(s) Morris Jr., R. C. (US)
Pravenec, Michal (FGU-C) RID, ORCID
Šilhavý, Jan (FGU-C) RID, ORCID
DiCarlo, S. E. (US)
Kurtz, T. W. (US)Source Title Hypertension. - : Lippincott Williams & Wilkins - ISSN 0194-911X
Roč. 73, č. 5 (2019), s. 1042-1048Number of pages 7 s. Language eng - English Country US - United States Keywords nitric oxide ; rats ; diet ; hypertension ; sodium Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery OECD category Cardiac and Cardiovascular systems Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000469352400023 EID SCOPUS 85064725302 DOI 10.1161/HYPERTENSIONAHA.118.12234 Annotation To reduce the risk of salt-induced hypertension, medical authorities have emphasized dietary guidelines promoting high intakes of potassium and low intakes of salt that provide molar ratios of potassium to salt of >= 1:1. However, during the past several decades, relatively few people have changed their eating habits sufficiently to reach the recommended dietary goals for salt and potassium. Thus, new strategies that reduce the risk of salt-induced hypertension without requiring major changes in dietary habits would be of considerable medical interest. In the current studies in a widely used model of salt-induced hypertension, the Dahl salt-sensitive rat, we found that supplemental dietary sodium nitrate confers substantial protection from initiation of salt-induced hypertension when the molar ratio of added nitrate to added salt is only approximate to 1:170. Provision of a low molar ratio of added nitrate to added salt of approximate to 1:110 by supplementing the diet with beetroot also conferred substantial protection against salt-induced increases in blood pressure. The results suggest that on a molar basis and a weight basis, dietary nitrate may be approximate to 100x more potent than dietary potassium with respect to providing substantial resistance to the pressor effects of increased salt intake. Given that leafy green and root vegetables contain large amounts of inorganic nitrate, these findings raise the possibility that fortification of salty food products with small amounts of a nitrate-rich vegetable concentrate may provide a simple method for reducing risk for salt-induced hypertension. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2020 Electronic address https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.118.12234
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