Number of the records: 1
Advances in Chemical Biology
- 1.
SYSNO ASEP 0502875 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title LINE-1 repression in human cancer Author(s) Epp, Trevor (UMG-J) RID
Schuster, Bjorn (UMG-J)
Chawengsaksophak, Kallayanee (UMG-J) ORCIDSource Title Advances in Chemical Biology. - Praha : OPTIO CZ, 2019 / Bartůněk Petr - ISBN 978-80-88011-03-3 Pages s. 64-75 Number of pages 9 s. Number of copy 50 Number of pages 210 Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords LINE-1 retrotransposon ; FAM208A ; human silencing hub Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects LO1220 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMG-J - RVO:68378050 Annotation The LINE-1 retrotransposon comprises 17% of the human genome, although only a few intact copies currently remain “hot”, capable of retrotransposition. LINE-1 elements have long been used as a cancer biomarker and, more recently, their expression has been associated with residual cancer stem cells resistant to chemotherapy. This poses a challenge as LINE-1 derepression can result in further cancer-driving mutations, both through somatic retrotransposition or through inter-LINE-1 recombination. FAM208A and other members of the HUSH (human silencing hub) complex have recently emerged as novel restriction factors for LINE-1 transposable elements. We will discuss these findings in context with previously known functions of the HUSH complex and discuss the prospectivity of targeting this complex for cancer treatment. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2019
Number of the records: 1