The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

0497329 - ÚACH 2019 RIV DE eng J - Journal Article
Hynek, Jan - Jurík, S. - Koncošová, M. - Zelenka, J. - Křížová, I. - Ruml, T. - Kirakci, Kaplan - Jakubec, Ivo - Kovanda, F. - Lang, Kamil - Demel, Jan
The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy.
Beilstein Journal of Nanotechnology. Roč. 9, NOV (2018), s. 2960-2967. ISSN 2190-4286. E-ISSN 2190-4286
R&D Projects: GA ČR(CZ) GA16-02098S
Institutional support: RVO:61388980
Keywords : metal-organic framework * phosphinic acid based MOF * photodynamic therapy * porphyrin * singlet oxygen
OECD category: Inorganic and nuclear chemistry
Impact factor: 2.269, year: 2018

Nanosized porphyrin-containing metal-organic frameworks (MOFs) attract considerable attention as solid-state photosensitizers for biological applications. In this study, we have for the first time synthesised and characterised phosphinate-based MOF nanoparticles, nanoICR-2 (Inorganic Chemistry Rez). We demonstrate that nanoICR-2 can be decorated with anionic 5,10,15,20-tetrakis(4-
R-phosphinatophenyl)porphyrins (R = methyl, isopropyl, phenyl) by utilizing unsaturated metal sites on the nanoparticle surface. The use of these porphyrins allows for superior loading of the nanoparticles when compared with commonly used 5,10,15,20-tetrakis(4-arboxyphenyl)porphyrin. The nanoICR-2/porphyrin composites retain part of the free porphyrins photophysical properties, while the photodynamic efficacy is strongly affected by the R substituent at the porphyrin phosphinate groups. Thus, phosphinatophenylporphyrin with phenyl substituents has the strongest photodynamic efficacy due to the most efficient cellular uptake.

Permanent Link: http://hdl.handle.net/11104/0290514