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Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins

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    0493265 - ÚACH 2019 RIV DE eng J - Journal Article
    Nekvinda, Jan - Grüner, Bohumír - Gabel, D. - Nau, W. M. - Assaf, K. I.
    Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins.
    Chemistry - A European Journal. Roč. 24, č. 49 (2018), s. 12970-12975. ISSN 0947-6539. E-ISSN 1521-3765
    Grant - others:AV ČR(CZ) DAAD-17-22
    Program: Bilaterální spolupráce
    Institutional support: RVO:61388980
    Keywords : boron * cluster compounds * carboranes * host-guest systems * hydrophobic effect
    OECD category: Inorganic and nuclear chemistry
    Impact factor: 5.160, year: 2018

    Polyhedral carboxymethyl carborane (C2B10H12) derivatives, including mono- and disubstituted o-, m-, and p-isomers, have been synthesized. Supramolecular host-guest complexation of these derivatives with cyclodextrins (CDs, namely, alpha-, beta-, and gamma-CD) has been investigated in water. The globular structure of the carborane binding moiety and its hydrophobic character qualify it as an ideal recognition site to form stable inclusion complexes with macrocyclic host molecules in aqueous solution. The measured binding affinities for the carborane derivatives were in the millimolar range (K-a=10(3)-10(4)m(-1)) with differently sized CDs, and preferential binding to beta-CD.
    Permanent Link: http://hdl.handle.net/11104/0286651


    Research data: Wiley onlinelibrary
     
     
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