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Cells in the non-uniform magnetic world: how cells respond to high-gradient magnetic fields
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SYSNO ASEP 0492453 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cells in the non-uniform magnetic world: how cells respond to high-gradient magnetic fields Author(s) Zablotskyy, Vitaliy A. (FZU-D) RID
Polyakova, Tetyana (FZU-D) ORCID
Dejneka, Alexandr (FZU-D) RID, ORCIDNumber of authors 3 Article number 1800017 Source Title BioEssays. - : Wiley - ISSN 0265-9247
Roč. 40, č. 8 (2018), s. 1-10Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords cell differentiation ; cell fate ; cell signaling ; intracellular forces ; magnetic fields ; magnetic gradient Subject RIV BO - Biophysics OECD category Biophysics Institutional support FZU-D - RVO:68378271 UT WOS 000439748100005 EID SCOPUS 85050404954 DOI 10.1002/bies.201800017 Annotation Imagine cells that live in a high-gradient magnetic field (HGMF). Through what mechanisms do the cells sense a non-uniform magnetic field and how such a field changes the cell fate? We show that magnetic forces generated by HGMFs can be comparable to intracellular forces and therefore may be capable of altering the functionality of an individual cell and tissues in unprecedented ways. We identify the cellular effectors of such fields and propose novel routes in cell biology predicting new biological effects such as magnetic control of cell-to-cell communication and vesicle transport, magnetic control of intracellular ROS levels, magnetically induced differentiation of stem cells, magnetically assisted cell division, or prevention of cells from dividing. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2019
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