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Cajal bodies and snRNPs friends with benefits
- 1.0487053 - ÚMG 2018 RIV US eng J - Journal Article
Staněk, David
Cajal bodies and snRNPs friends with benefits.
RNA biology. Roč. 14, č. 6 (2017), s. 671-679. ISSN 1547-6286. E-ISSN 1555-8584
R&D Projects: GA ČR GA15-00790S
Institutional support: RVO:68378050
Keywords : spinal muscular-atrophy * small nuclear-rna * u4/u6.u5 tri-snrnp * xenopus-laevis oocytes * u6 spliceosomal rna * coiled bodies * smn complex * u1 snrnp * u2 snrnp * in-vivo
OECD category: Cell biology
Impact factor: 5.216, year: 2017
Spliceosomal snRNPs are complex particles that proceed through a fascinating maturation pathway. Several steps of this pathway are closely linked to nuclear non-membrane structures called Cajal bodies. In this review, I summarize the last 20 y of research in this field. I primarily focus on snRNP biogenesis, specifically on the steps that involve Cajal bodies. I also evaluate the contribution of the Cajal body in snRNP quality control and discuss the role of snRNPs in Cajal body formation.
Permanent Link: http://hdl.handle.net/11104/0281743
Number of the records: 1