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Distinguishing glycan isomers by voltammetry. Modification of 2,3-sialyllactose and 2,6-sialyllactose by osmium(VI) complexes
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SYSNO ASEP 0486056 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Distinguishing glycan isomers by voltammetry. Modification of 2,3-sialyllactose and 2,6-sialyllactose by osmium(VI) complexes Author(s) Trefulka, Mojmír (BFU-R) RID, ORCID
Paleček, Emil (BFU-R) RID, ORCIDNumber of authors 2 Source Title Electrochemistry Communications. - : Elsevier - ISSN 1388-2481
Roč. 85, DEC2017 (2017), s. 19-22Number of pages 4 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords prostate-specific antigen ; maldi-tof-ms ; os(vi)-modified polysaccharides Subject RIV CG - Electrochemistry OECD category Analytical chemistry R&D Projects GA15-15479S GA ČR - Czech Science Foundation (CSF) Institutional support BFU-R - RVO:68081707 UT WOS 000415112500005 DOI 10.1016/j.elecom.2017.10.014 Annotation Carbohydrate components in glycoproteins play a critical role in health and disease and specificity of glycoprotein biomarkers can be greatly enhanced by analysis of their sugar components containing frequently different isomers. We show that two glycan isomers, 2,3-sialyllactose and 2,6-sialyllactose (important in cancer), can be distinguished voltammetrically after their modification with osmium(VI) complexes. Using SWV at different frequencies and CV at different scan rates we found conditions for simple discrimination between these isomers at mercury and carbon electrodes. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2018
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