Number of the records: 1
Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon
- 1.
SYSNO ASEP 0483638 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon Author(s) Polidarová, Lenka (FGU-C) RID, ORCID
Houdek, Pavel (FGU-C) ORCID
Sumová, Alena (FGU-C) RID, ORCIDSource Title Chronobiology International - ISSN 0742-0528
Roč. 34, č. 9 (2017), s. 1273-1287Number of pages 15 s. Language eng - English Country US - United States Keywords aging ; colon ; constant light ; melatonin ; proinflammatory cytokine ; Rgs16 ; sleep disruption Subject RIV ED - Physiology OECD category Physiology (including cytology) R&D Projects GA14-07711S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000418361300011 EID SCOPUS 85031506158 DOI 10.1080/07420528.2017.1361436 Annotation Exposure to environmental conditions that disturb the daily rhythms has been shown to enhance the proinflammatory responses of immunostimulant-challenged immune system. However, it is not known whether circadian disturbances may stimulate unchallenged immune responses and thus contribute per se to the development of inflammation-related diseases. Our aim was to ascertain an effect of various conditions threatening the behavioral activity/rest cycle regulation, namely aging with or without melatonin, 6-h advance/delay phase shifts in the light/dark cycle repeated with a 2-day frequency and constant light, on expression of immune markers in the rat colon. We detected impact of these conditions on parameters of behavioral activity and mRNA levels of selected immune markers in the colonic mucosa of Wistar rats, namely TNFa (Tnf), IL1a (Il1a), IL17RA (Il17ra), STAT3 (Stat3), and Rgs16 (Rsg16), were detected. Exposure to constant light, which perturbed the interval of inactivity (sleep) and led to the complete abolishment of activity/inactivity cycles, activated robustly proinflammatory state in the colon selectively via Stat3-dependent pathway. These results provided the first evidence that disruptions in the behavioral activity/inactivity cycles may spontaneously (without immuno-stimulant) induce selective proinflammatory responses in the colonic mucosa. Such effects may take part in the mechanisms of modern lifestyle-induced inflammatory diseases of the gut. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2018
Number of the records: 1