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Radiomodifying effects of RAPTA C and CDDP on DNA strand break induction
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SYSNO ASEP 0480615 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Radiomodifying effects of RAPTA C and CDDP on DNA strand break induction Author(s) Reimitz, D. (CZ)
Davídková, Marie (UJF-V) RID, ORCID, SAI
Mestek, O. (CZ)
Pinkas, Jiří (UFCH-W) RID, ORCID
Kočišek, Jaroslav (UFCH-W) RID, ORCIDNumber of authors 5 Source Title Radiation Physics and Chemistry. - : Elsevier - ISSN 0969-806X
Roč. 141, DEC (2017), s. 229-234Number of pages 6 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords RAPTA C ; Cisplatin ; chemoradiation synergy ; low energy electrons ; DNA plasmid Subject RIV BO - Biophysics OECD category Biophysics Subject RIV - cooperation J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry R&D Projects GJ16-10995Y GA ČR - Czech Science Foundation (CSF) LM2015056 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UJF-V - RVO:61389005 ; UFCH-W - RVO:61388955 UT WOS 000412607700035 EID SCOPUS 85025710278 DOI 10.1016/j.radphyschem.2017.07.015 Annotation Experimental study is exploring combined effect of RAPTA C (Ru(eta(6)-p-cymene)Cl-2(1,3,5-triaza-7-phosphatricyclo-[3.3.1.1.]clecanephosphine)) or CDDP (cis-diamminedichloridoplatinum(M) and radiation on the DNA damage. When irradiating plasmid DNA in solution with free molecules, no combined effect is observed, indicating that the contribution to DNA damage caused by products of radiolysis of RAPTA C or CDDP is negligible in comparison to the damage caused by products of radiolysis of water. After binding to DNA, CDDP adducts with DNA strongly enhance the damage in a good agreement with the results of previous studies. RAPTA C adducts act radio-protective at low doses of OH radical scavenger - tris(hydroxymethyl)aminomethane (iris) and show no combined effects at higher tris levels. Radioprotectivity of RAPTA C is therefore primarily caused by enhanced resistance of RAPTA C modified DNA against the damage induced by radicals. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2018
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