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The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis
- 1.0463355 - MBÚ 2017 RIV US eng J - Journal Article
Heissigerová, J. - Seidler Stangová, P. - Klímová, A. - Svozilová, P. - Hrnčíř, Tomáš - Štěpánková, Renata - Kverka, Miloslav - Tlaskalová-Hogenová, Helena - Forrester, J.V.
The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis.
Journal of Immunology Research. Roč. 2016, č. 1 (2016), s. 1-11. ISSN 2314-8861. E-ISSN 2314-7156
R&D Projects: GA ČR(CZ) GA15-09518S; GA MZd NT14017
Institutional support: RVO:61388971
Keywords : GUT MICROBIOTA * T-CELL * INFLAMMATION
Subject RIV: EC - Immunology
Impact factor: 3.276, year: 2016
The microbiota is a crucial modulator of the immune system. Here, we evaluated how its absence or reduction modifies the inflammatory response in the murine model of experimental autoimmune uveoretinitis (EAU). We induced EAU in germ-free (GF) or conventionally housed (CV) mice and in CV mice treated with a combination of broad-spectrum antibiotics either from the day of EAU induction or from one week prior to induction of disease. The severity of the inflammation was assessed by fundus biomicroscopy or by histology, including immunohistology. The immunophenotyping of T cells in local and distant lymph nodes was performed by flow cytometry.
Permanent Link: http://hdl.handle.net/11104/0263322
Number of the records: 1