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Nanobiomaterials in Hard Tissue Engineering
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SYSNO ASEP 0458563 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Nanostructured materials as substrates for the adhesion, growth, and osteogenic differentiation of bone cells Author(s) Bačáková, Lucie (FGU-C) RID, ORCID
Filová, Elena (FGU-C) RID, ORCID
Lišková, Jana (FGU-C) RID, ORCID
Kopová, Ivana (FGU-C) RID
Vandrovcová, Marta (FGU-C) RID, ORCID
Havlíková, Jana (FGU-C)Source Title Nanobiomaterials in Hard Tissue Engineering. - Amsterdam : Elsevier, 2016 / Grumezescu Alexandru Mihai - ISBN 978-0-323-42862-0 Pages s. 103-153 Number of pages 51 s. Number of pages 484 Publication form Print - P Language eng - English Country NL - Netherlands Keywords bone tissue engineering ; nanoroughness ; osteoblast ; alloys ; carbon coating ; ceramics ; porous scaffold ; nanofibers ; nanoparticles Subject RIV EI - Biotechnology ; Bionics R&D Projects GBP108/12/G108 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 EID SCOPUS 84967212142 DOI 10.1016/B978-0-323-42862-0.00004-3 Annotation Nanostructured materials, particularly those with hierarchically organized macro-, micro-, and nanostructure, imitating the architecture of the natural bone tissue, are promising materials for construction of bone implants and bone tissue engineering. The nanoscale surface roughness has been unambiguously considered as a factor positively influencing the adhesion, growth, and phenotypic maturation of cells. The explanation is that the nanosized irregularities on a material surface mimic the nanoscale architecture of the native ECM. Materials already used or developed for bone implantation and bone tissue engineering can be divided into two basic groups: materials interacting with cells only on their surface, referred as two-dimensional (2D) materials, and materials enabling the ingrowth of cell into their inner structure, referred as three-dimensional (3D) materials. On 2D surfaces, the nanoscale features can be achieved by two main types of modification: subtractive and additive. Both technologies have been often combined. In 3D materials, nanostructure can be achieved by, for example, reinforcing macro- or microporous and micro- or nanofibrous polymeric scaffolds with ceramic, carbon-based, metal-based, or other nanoparticles. In this chapter, we summarize our experience and the experience of other authors concerning the adhesion, growth, and differentiation of osteogenic cells on 2D and 3D materials containing nanoscale features created by various technologies. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
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