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Telomere Length in Circulating Lymphocytes: Association with Chromosomal Aberrations
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SYSNO ASEP 0452273 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Telomere Length in Circulating Lymphocytes: Association with Chromosomal Aberrations Author(s) Hemminki, K. (DE)
Rachakonda, S. (DE)
Musak, L. (SK)
Vymetálková, Veronika (UEM-P) RID
Halasová, E. (SK)
Forsti,, A. (DE)
Vodičková, Ludmila (UEM-P) RID
Buchancová, J. (SK)
Vodička, Pavel (UEM-P) RID
Kumar, R. (DE)Number of authors 10 Source Title Genes Chromosomes & Cancer. - : Wiley - ISSN 1045-2257
Roč. 54, č. 3 (2015), s. 194-196Number of pages 3 s. Language eng - English Country US - United States Keywords structural chromosome aberrations ; healthy subjects ; relative telomere length ; genotoxicity ; telomere biology Subject RIV EB - Genetics ; Molecular Biology Institutional support UEM-P - RVO:68378041 UT WOS 000348577000007 EID SCOPUS 84921460776 DOI 10.1002/gcc.22225 Annotation Nonspecific chromosomal aberrations (CAs) are analyzed by microscopic scoring of metaphase nuclei and they include fragmented, missing, or fused chromosomal segments which may not be clonally expanded but remain in lymphocytes for their life-time. CAs are a marker of cancer risk and many specific CAs are believed to be causative events in malignant transformation. However, it has recently been realized that, instead of direct DNA damage, mechanisms associated with telomere biology are important contributors to formation of CAs, preferentially of CSA type. In this study, we measured relative telomere length (RTL) in lymphocytes of healthy volunteers whose CAs have been quantified and classified as either CSA or CTA. The median RTL was 1.28 for 48 subjects showing no CAs, and 1.19 for 47 individuals with a total of more than 2 CAs (P=0.03). Further decreased median RTL (1.12) was recorded in 68 individuals with CSAs (P=0.001). These results, together with similar data by Li et al. (2013), provide strong evidence that telomere biology contributes to CA formation, particularly of the CSA type, in healthy individuals and that direct genotoxic mechanisms are not the only causal pathways. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2016
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