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APOE and spatial navigation in amnestic MCI: Results from a computer-based test
- 1.0437833 - FGÚ 2015 RIV US eng J - Journal Article
Laczó, J. - Andel, R. - Vyhnálek, M. - Vlček, Kamil - Nedělská, Z. - Maťoška, V. - Gažová, I. - Mokrišová, I. - Sheardová, K. - Hort, J.
APOE and spatial navigation in amnestic MCI: Results from a computer-based test.
Neuropsychology. Roč. 28, č. 5 (2014), s. 676-684. ISSN 0894-4105. E-ISSN 1931-1559
R&D Projects: GA ČR(CZ) GA309/09/1053; GA ČR(CZ) GA309/09/0286
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : mild cognitive impairment * spatial navigation * Alzheimer's Disease * apolipoprotein E * hippocampus
Subject RIV: FH - Neurology
Impact factor: 3.269, year: 2014
We compared groups of amnestic mild cognitive impairment (aMCI) patients with different ApoE status. The groups had similar neuropsychological profile, but more profound deficits in spatial navigation were found in aMCI E4 positive relative to aMCI E4 negative patients and E4 heterozygotes. Thus, the higher probability of developing AD in E4 positive aMCI corresponds with their impaired spatial orientation
Permanent Link: http://hdl.handle.net/11104/0241315
Number of the records: 1