Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress

0428971 - FGÚ 2015 RIV CZ eng J - Journal Article
Garnol, T. - Endlicher, R. - Kučera, O. - Drahota, Zdeněk - Červinková, Z.
Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress.
Physiological Research. Roč. 63, č. 2 (2014), s. 271-274. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LL1204
Grant - others:Univerzita Karlova(CZ) PRVOUK P37/02
Institutional support: RVO:67985823
Keywords : hepatocytes * high fat diet * mitochondrial activities * ROS
Subject RIV: ED - Physiology
Impact factor: 1.293, year: 2014

Fatty liver disease associated with obesity is an important medical problem. Our data extend observations obtained on isolated mitochondria and confirm inhibition of Complex I activity in hepatocytes by high fat diet (HFD). In HFD-hepatocytes also Complex II activity is disturbed, therefore it cannot compensate the decrease of Complex I activity. Our data thus indicate that combination of HFD and peroxidative stress potentiates HFD damaging effect of mitochondria because both branches of the respiratory chain are disturbed
Permanent Link: http://hdl.handle.net/11104/0234191