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Asymmetric transfer hydrogenation of 1-phenyl dihydroisoquinolines using Ru(II) diamine catalysts
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SYSNO ASEP 0425836 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Asymmetric transfer hydrogenation of 1-phenyl dihydroisoquinolines using Ru(II) diamine catalysts Author(s) Přech, J. (CZ)
Václavík, J. (CZ)
Šot, P. (CZ)
Pecháček, J. (CZ)
Vilhanová, B. (CZ)
Januščák, J. (CZ)
Syslová, K. (CZ)
Pažout, R. (CZ)
Maixner, J. (CZ)
Zápal, Jakub (MBU-M)
Kuzma, Marek (MBU-M) ORCID, RID
Kačer, P. (CZ)Source Title Catalysis Communication. - : Elsevier - ISSN 1566-7367
Roč. 36, JUN 2013 (2013), s. 67-70Number of pages 4 s. Language eng - English Country NL - Netherlands Keywords Asymmetric transfer hydrogenation ; N-alkylsulfonyl ; Dihydroisoquinoline Subject RIV CA - Inorganic Chemistry R&D Projects GA104/09/1497 GA ČR - Czech Science Foundation (CSF) GAP106/12/1276 GA ČR - Czech Science Foundation (CSF) Institutional support MBU-M - RVO:61388971 UT WOS 000318464400014 DOI 10.1016/j.catcom.2013.03.004 Annotation We present, to the best of our knowledge, the first parametric study of the asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type catalytic complex based on ruthenium. A model imine for this study was 1-methyl-3,4-dihydroisoquinoline, and a well-known complex RuCl(eta(6)-p-cymene)((1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine) was chosen as the model catalyst. The reactions were performed in the presence of a formic acid-triethylamine mixture as the source of hydrogen. The parameters examined include general parameters, for example, concentration, temperature, and substrate-to-catalyst molar ratio, as well as parameters specific to this particular reaction, such as the amount of the hydrogenation mixture used, the ratio of its components, or the inhibitive effect of carbon dioxide. During this study, several unexpected parameters worth further investigation have emerged. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2014
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