Mast cell chemotaxis - chemoattractants and signaling pathways

0386049 - ÚMG 2013 RIV CH eng J - Journal Article
Hálová, Ivana - Dráberová, Lubica - Dráber, Petr
Mast cell chemotaxis - chemoattractants and signaling pathways.
Frontiers in Immunology. Roč. 3, May (2012), s. 119. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA MŠMT LD12073; GA ČR GA301/09/1826; GA ČR GAP302/10/1759
Grant - others:ECST(XE) BM1007; AV ČR(CZ) MC200520901
Institutional support: RVO:68378050
Keywords : mast cell * IgE receptor * plasma membrane
Subject RIV: EB - Genetics ; Molecular Biology

Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react to them by a chemotactic response. Another level of intercellular communication is attained by production of chemoattractants by activated mast cells, which results in accumulation of mast cells and other hematopoietic cells at the sites of inflammation. Mast cells express numerous surface receptors for various ligands with properties of potent chemoattractants. They include the stem cell factor (SCF) recognized by c-Kit, antigen, which binds to immunoglobulin E (IgE) anchored to the high affinity IgE receptor (FcεRI), highly cytokinergic (HC) IgE recognized by FcεRI, lipid mediator sphingosine-1-phosphate (S1P), which binds to G protein-coupled receptors (GPCRs). Other large groups of chemoattractants are eicosanoids [prostaglandin E(2) and D(2), leukotriene (LT) B(4), LTD(4), and LTC(4), and others] and chemokines (CC, CXC, C, and CX3C), which also bind to various GPCRs. Further noteworthy chemoattractants are isoforms of transforming growth factor (TGF) β1-3, which are sensitively recognized by TGF-β serine/threonine type I and II β receptors, adenosine, C1q, C3a, and C5a components of the complement, 5-hydroxytryptamine, neuroendocrine peptide catestatin, tumor necrosis factor-α, and others. Here we discuss the major types of chemoattractants recognized by mast cells, their target receptors, as well as signaling pathways they utilize. We also briefly deal with methods used for studies of mast cell chemotaxis and with ways of how these studies profited from the results obtained in other cellular systems.
Permanent Link: http://hdl.handle.net/11104/0216391