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Functional, genetic and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas
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SYSNO ASEP 0385619 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Functional, genetic and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas Author(s) Slyšková, Jana (UEM-P) RID
Korenková, Vlasta (BTO-N) RID
Collins, A. R. (NO)
Procházka, Pavel (UEM-P) RID
Vodičková, Ludmila (UEM-P) RID
Švec, Jiří (UEM-P)
Lipská, L. (CZ)
Levý, M. (CZ)
Schneiderová, M. (CZ)
Liška, V. (CZ)
Holubec, L. (CZ)
Kumar, R. (DE)
Souček, P. (CZ)
Naccarati, Alessio (UEM-P)
Vodička, Pavel (UEM-P) RIDSource Title Clinical Cancer Research. - : American Association for Cancer Research - ISSN 1078-0432
Roč. 18, č. 21 (2012), s. 5878-5887Number of pages 10 s. Language eng - English Country US - United States Keywords DNA repair capacity ; DNA repair gene expression ; methylation Subject RIV EB - Genetics ; Molecular Biology R&D Projects GAP304/12/1585 GA ČR - Czech Science Foundation (CSF) GAP304/10/1286 GA ČR - Czech Science Foundation (CSF) NT12025 GA MZd - Ministry of Health (MZ) Institutional support UEM-P - RVO:68378041 ; BTO-N - RVO:86652036 CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000312020400008 DOI 10.1158/1078-0432.CCR-12-1380 Annotation For the first time, we have evaluated both base and nucleotide excision repair capacities in human colon biopsies to study their participation in colorectal tumorigenesis. Our complex analysis showed that tumor cells are not deficient in studied pathways, but rather follow patterns characteristic for each individual and are comparable with adjacent tissue. This study further shows the feasibility of DRC evaluation in human solid tissues, representing a complex marker of multigene DNA repair processes. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2013
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