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Segregation of calcium signalling mechanisms in magnocellular neurones and terminals
- 1.0383855 - ÚEM 2013 RIV DE eng J - Journal Article
Dayanithi, Govindan - Forostyak, Oksana - Ueta, Y. - Verkhratsky, Alexei - Toescu, E.C.
Segregation of calcium signalling mechanisms in magnocellular neurones and terminals.
Cell Calcium. Roč. 51, 3-4 (2012), s. 293-299. ISSN 0143-4160. E-ISSN 1532-1991
R&D Projects: GA ČR(CZ) GAP303/11/0192
Institutional research plan: CEZ:AV0Z50390703
Keywords : Ca2+ stores * Mitochondria * Endoplasmic reticulum
Subject RIV: FH - Neurology
Impact factor: 4.327, year: 2012
The present study has highlighted the mechanisms involved in Ca2+ homeostasis and Ca2+ clearance processes both in the cell bodies and the nerve terminals of the vasopressin (AVP) and oxytocin (OT) neurones in the supraoptic nucleus, using both the normal rat model and the recently developed transgenic rat with specific fluorescence labelling for AVP and OT. The physiological significance of the complexity of Ca2+ homeostatic mechanisms in the somatodendritic region of supraoptic neurones and their terminals can be multifaceted, attributable, in major part, to their specialized electrical activity and Ca2+-dependent neurohormone release.
Permanent Link: http://hdl.handle.net/11104/0213667
Number of the records: 1