Synthesis and biological properties of the 2’-trifluoromethyl analogues of tenofovir

0361088 - ÚOCHB 2012 CZ eng C - Conference Paper (international conference)
Jansa, Petr - Kolman, Viktor - Janeba, Zlatko
Synthesis and biological properties of the 2’-trifluoromethyl analogues of tenofovir.
Chemistry of Nucleic Acid Components. 15th Symposium. Praha: Institute of Organic Chemistry and Biochemistry AS CR, v. v. i., 2011 - (Hocek, M.), s. 370-371. Collection Symposium Series, 12. ISBN 978-80-86241-37-1.
[Chemistry of Nucleic Acid Components /15./. Český Krumlov (CZ), 05.06.2011-10.06.2011]
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : ANPs * acyclic nucleoside phosphonates * trifluoromethyl group
Subject RIV: CC - Organic Chemistry

A series of acyclic nucleoside phosphonates substituted at the aliphatic part of the molecule by the trifluoromethyl group was prepared but none of the compounds exhibits any anti-HIV or anti-HCV activities.
Permanent Link: http://hdl.handle.net/11104/0198497