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Future use of mitocans against tumour-initiating cells?
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SYSNO ASEP 0325050 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Future use of mitocans against tumour-initiating cells? Author(s) Morrison, B.J. (AU)
Anděra, Ladislav (UMG-J) RID
Reynolds, B.A. (AU)
Ralph, S.J. (AU)
Neužil, Jiří (BTO-N) RIDNumber of authors 5 Source Title Molecular Nutrition & Food Research. - : Wiley - ISSN 1613-4125
Roč. 53, č. 1 (2009), s. 147-153Number of pages 7 s. Language eng - English Country DE - Germany Keywords mitocans ; tumour-initiating cells ; metastasis Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50520701 - BTO-N (2007-2013) UT WOS 000262869400013 DOI 10.1002/mnfr.200800254 Annotation Tumour heterogeneity has several important consequences including making their classification by morphological and genetic analysis more difficult because of the diversity of cells, failing to eliminate one of the cell subtypes and differing abilities of the cell subtypes for dissemination and metastasis. Recently, a rare subpopulation of cells within tumours has been described with the ability to initiate and sustain tumour growth, to resist traditional therapies and to allow for secondary tumour dissemination. These cells are termed tumour-initiating cells (TICs). Understanding tumour heterogeneity will be critical for advancing treatments for cancer that target TIC subpopulations of cells in a tumour able to resist traditional treatments and eliminate them before metastatic disease occurs. Therefore, knowledge of the molecular mechanism(s) of resistance of TICs to treatment and overcoming it will be essential in order to develop effective drug strategies for cancer therapy. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2010
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