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Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine
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SYSNO ASEP 0310039 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Nucleosides and nucleotides containing 8-aza-7,9-dideazaxanthine Title Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin Author(s) Mařák, David (UOCHB-X) RID
Otmar, Miroslav (UOCHB-X) RID
Dračínský, Martin (UOCHB-X) RID, ORCID
Votruba, Ivan (UOCHB-X) RID
Holý, Antonín (UOCHB-X)Source Title Chemistry of Nucleic Acid Components. - Praha : Institute of Organic Chemistry and Biochemistry ASCR, 2008 / Hocek Michal - ISBN 978-80-86241-29-6 Pages s. 426-428 Number of pages 3 s. Action Symposium on Chemistry of Nucleic Acid Components /14./ Event date 08.06.2008-13.06.2008 VEvent location Český Krumlov Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords 8-Aza-7,9-dideaza ; xanthine ; thymidine phosporylase ; debenzylation Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS400550501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000257885700102 Annotation The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2009
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