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Density-related changes in selection pattern for major histocompatibility complex genes in fluctuating populations of voles
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SYSNO ASEP 0090913 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Density-related changes in selection pattern for major histocompatibility complex genes in fluctuating populations of voles Title Typ selekce působící na geny hlavního histokompatibilního systému u hrabošů závisí na hustotě Author(s) Bryja, Josef (UBO-W) RID, SAI, ORCID
Charbonnel, N. (FR)
Berthier, K. (FR)
Galan, M. (FR)
Cosson, J.-F. (FR)Source Title Molecular Ecology. - : Wiley - ISSN 0962-1083
Roč. 16, č. 23 (2007), s. 5084-5097Number of pages 14 s. Language eng - English Country GB - United Kingdom Keywords Arvicola terrestris ; balancing selection ; local adaptation ; MHC ; population cycles Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA600930608 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Next source Framework programmes of European Commission CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000251205200018 EID SCOPUS 36348998788 DOI 10.1111/j.1365-294X.2007.03584.x Annotation We investigated whether two MHC class II genes (DQA1, DRB) were subjected to contemporary selection during increases in the density of fossorial water vole (Arvicola terrestris) populations. In the low-abundance phase, when populations were geographically isolated, both overall differentiation and isolation-by-distance were more marked for MHC genes than for neutral markers. Model-based simulations identified DQA1 as an outlier (i.e. under selection) in a single population, suggesting the action of local selection in fragmented populations. The differences between MHC and neutral markers gradually disappeared with increasing effective migration between sites. In the high-abundance year, DQA1 displayed significantly lower levels of overall differentiation than the neutral markers. Spatial and temporal fluctuations in parasite pressure and locus-specific selection are probably the most plausible mechanisms underlying the observed changes in selection pattern during the demographic cycle. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2008
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