Number of the records: 1
The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways
- 1.
SYSNO ASEP 0583021 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways Author(s) Obšilová, Veronika (FGU-C) RID, ORCID, SAI
Obšil, T. (CZ)Number of authors 2 Article number 1327014 Source Title Frontiers in molecular biosciences
Roč. 11, Jan 24 (2024)Number of pages 12 s. Language eng - English Country CH - Switzerland Keywords 14-3-3 proteins ; yeast ; protein-protein interaction ; phosphorylation ; molecular mechanism ; scaffolding ; adaptor protein OECD category Biochemical research methods R&D Projects GA23-04686S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001157336400001 EID SCOPUS 85184217430 DOI 10.3389/fmolb.2024.1327014 Annotation Cell signaling regulates several physiological processes by receiving, processing, and transmitting signals between the extracellular and intracellular environments. In signal transduction, phosphorylation is a crucial effector as the most common posttranslational modification. Selectively recognizing specific phosphorylated motifs of target proteins and modulating their functions through binding interactions, the yeast 14-3-3 proteins Bmh1 and Bmh2 are involved in catabolite repression, carbon metabolism, endocytosis, and mitochondrial retrograde signaling, among other key cellular processes. These conserved scaffolding molecules also mediate crosstalk between ubiquitination and phosphorylation, the spatiotemporal control of meiosis, and the activity of ion transporters Trk1 and Nha1. In humans, deregulation of analogous processes triggers the development of serious diseases, such as diabetes, cancer, viral infections, microbial conditions and neuronal and age-related diseases. Accordingly, the aim of this review article is to provide a brief overview of the latest findings on the functions of yeast 14-3-3 proteins, focusing on their role in modulating the aforementioned processes. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2025 Electronic address https://doi.org/10.3389/fmolb.2024.1327014
Number of the records: 1