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Exceptionally fast temperature-responsive, mechanically strong and extensible monolithic non-porous hydrogels: poly(N-isopropylacrylamide) intercalated with hydroxypropyl methylcellulose
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SYSNO ASEP 0580772 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Exceptionally fast temperature-responsive, mechanically strong and extensible monolithic non-porous hydrogels: poly(N-isopropylacrylamide) intercalated with hydroxypropyl methylcellulose Author(s) Strachota, Beata (UMCH-V) RID
Strachota, Adam (UMCH-V) RID, ORCID
Vratović, Leana (UMCH-V)
Pavlova, Ewa (UMCH-V) RID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Kamel, S. (EG)
Cimrová, Věra (UMCH-V) RID, ORCIDArticle number 926 Source Title Gels. - : MDPI
Roč. 9, č. 12 (2023)Number of pages 25 s. Language eng - English Country CH - Switzerland Keywords hydrogels ; drug release ; smart materials Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 001131988500001 EID SCOPUS 85180715788 DOI 10.3390/gels9120926 Annotation Exceptionally fast temperature-responsive, mechanically strong, tough and extensible monolithic non-porous hydrogels were synthesized. They are based on divinyl-crosslinked poly(N-isopropyl-acrylamide) (PNIPAm) intercalated by hydroxypropyl methylcellulose (HPMC). HPMC was largely extracted after polymerization, thus yielding a ‘template-modified’ PNIPAm network intercalated with a modest residue of HPMC. High contents of divinyl crosslinker and of HPMC caused a varying degree of micro-phase-separation in some products, but without detriment to mechanical or tensile properties. After extraction of non-fixed HPMC, the micro-phase-separated products combine superior mechanical properties with ultra-fast T-response (in 30 s). Their PNIPAm network was highly regular and extensible (intercalation effect), toughened by hydrogen bonds to HPMC, and interpenetrated by a network of nano-channels (left behind by extracted HPMC), which ensured the water transport rates needed for ultra-fast deswelling. Moreover, the T-response rate could be widely tuned by the degree of heterogeneity during synthesis. The fastest-responsive among our hydrogels could be of practical interest as soft actuators with very good mechanical properties (soft robotics), while the slower ones offer applications in drug delivery systems (as tested on the example of Theophylline), or in related biomedical engineering applications. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2024 Electronic address https://www.mdpi.com/2310-2861/9/12/926
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