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NMR investigation of a high-affinity ruthenium-based galectin-1 inhibitor
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SYSNO ASEP 0575606 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title NMR investigation of a high-affinity ruthenium-based galectin-1 inhibitor Author(s) Kurfiřt, Martin (UCHP-M) RID, ORCID, SAI
Hamala, Vojtěch (UCHP-M) RID, SAI, ORCID
Ardá, A. (ES)
Jiménez-Barbero, J. (ES)
Karban, Jindřich (UCHP-M) RID, ORCID, SAIArticle number P23 Source Title Abstracts Posters. - Prague : NMR Spectroscopy Research Service Group, 2023
S. 36Number of pages 1 s. Publication form Online - E Action The Central European NMR Symposium & Bruker Users Meeting CEUM 20232023 Event date 13.09.2023 - 15.09.2023 VEvent location Prague Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords galectin-1 ; ruthenium complexes ; NMR-spectroscopy OECD category Analytical chemistry Institutional support UCHP-M - RVO:67985858 Annotation This work focuses on the QM-assisted NMR investigation of a novel N-acetyllactosamine-based piano stool ruthenium complex, which showed promising selectivity to human galectin-1 over galectin-3. To decipher the structural basis of molecular recognition, we studied this process by established NMR methods such as 1H-1H transferred NOESY, 1H-1H saturation transfer difference, or 1H-15N chemical shift perturbation. The investigation provided a reasonable explanation for the selectivity with implications for galectin-focused medici nal chemistry. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2024
Number of the records: 1