Effects of gradient high-field static magnetic fields on diabetic mice

0570706 - FZÚ 2024 RIV CN eng J - Journal Article
Yu, B. - Song, C. - Feng, C.-L. - Zhang, J. - Wang, Y. - Zhu, Y.-M. - Zhang, L. - Ji, X.-M. - Tian, X.-F. - Cheng, G.-F. - Chen, W.-L. - Zablotskii, Vitalii - Wang, H. - Zhang, X.
Effects of gradient high-field static magnetic fields on diabetic mice.
ZOOLOGICAL RESEARCH. Roč. 44, č. 2 (2023), s. 249-258. ISSN 2095-8137
Institutional support: RVO:68378271
Keywords : type 2 diabetes * type 1 diabetes * magnetic resonance imaging (MRI) * gradient static magnetic field * quasi-uniform static magnetic field
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 4.9, year: 2022
Method of publishing: Open access

Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety in diabetic patients is unclear. Furthermore, the effects of high static magnetic fields (SMFs), especially gradient vs. uniform fields, have not been investigated in diabetics. Here, we investigated the consequences of exposure to 1.0–9.4 T high SMFs of different gradients (>10 T/m vs. 0–10 T/m) on type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. We found that 14 h of prolonged treatment of gradient (as high as 55.5 T/m) high SMFs (1.0–8.6 T) had negative effects on T1D and T2D mice, including spleen, hepatic, and renal tissue impairment and elevated glycosylated serum protein, blood glucose, inflammation, and anxiety, while 9.4 T quasi-uniform SMFs at 0–10 T/m did not induce the same effects. In regular T1D mice (blood glucose ≥16.7 mM), the >10 T/m gradient high SMFs increased malondialdehyde (P<0.01) and decreased superoxide dismutase (P<0.05).
Permanent Link: https://hdl.handle.net/11104/0342031