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Transcriptional regulators of human oncoviruses: structural and functional implications for anticancer therapy
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SYSNO ASEP 0569833 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Transcriptional regulators of human oncoviruses: structural and functional implications for anticancer therapy Author(s) Nečasová, Ivona (BFU-R)
Stojaspal, Martin (BFU-R)
Motyčáková, Edita (BFU-R)
Brom, T. (CZ)
Janovic, T. (CZ)
Hofr, Ctirad (BFU-R) ORCIDNumber of authors 6 Source Title NAR CANCER. -, 2022 - ISSN 2632-8674
Roč. 4, č. 1 (2022)Number of pages 16 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords EPSTEIN-BARR-VIRUS ; T-CELL LEUKEMIA ; X-PROTEIN Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 000925421400008 EID SCOPUS 85141079091 DOI 10.1093/narcan/zcac005 Annotation Transcription is often the first biosynthetic event of viral infection. Viruses produce preferentially viral transcriptional regulators (vTRs) essential for expressing viral genes and regulating essential host cell proteins to enable viral genome replication. As vTRs are unique viral proteins that promote the transcription of viral nucleic acid, vTRs interact with host proteins to suppress detection and immune reactions to viral infection. Thus, vTRs are promising therapeutic targets that are sequentially and structurally distinct from host cell proteins. Here, we review vTRs of three human oncoviruses: HBx of hepatitis B virus, HBZ of human T-lymphotropic virus type 1, and Rta of Epstein-Barr virus. We present three cunningly exciting and dangerous transcription strategies that make viral infections so efficient. We use available structural and functional knowledge to critically examine the potential of vTRs as new antiviral-anticancer therapy targets. For each oncovirus, we describe (i) the strategy of viral genome transcription, (ii) vTRs' structure and binding partners essential for transcription regulation, and (iii) advantages and challenges of vTR targeting in antiviral therapies. We discuss the implications of vTR regulation for oncogenesis and perspectives on developing novel antiviral and anticancer strategies. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2023 Electronic address https://academic.oup.com/narcancer/article/4/1/zcac005/6541525?login=true
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