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Possibilities of Influencing Procedural Pain Associated with Premature Newborn Retinopathy Screening with Oral Clonidine
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SYSNO ASEP 0567292 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Possibilities of Influencing Procedural Pain Associated with Premature Newborn Retinopathy Screening with Oral Clonidine Author(s) Dušek, J. (CZ)
Šimková, E. (CZ)
Fendrstatová, E. (CZ)
Šrám, Radim (UEM-P) RID
Kotoučková, H. (CZ)
Voráček, J. (CZ)Article number 1659 Source Title CHILDREN-BASEL
Roč. 9, č. 11 (2022)Number of pages 11 s. Language eng - English Country CH - Switzerland Keywords clonidine ; oxybuprocaine hydrochloride 0.4% ; procedural pain ; retinopathy in premature newborns OECD category Public and environmental health R&D Projects EF16_019/0000798 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000882674300001 EID SCOPUS 85141779042 DOI 10.3390/children9111659 Annotation Background: The aim of our study was to compare the analgesic/sedative effects of various fundus-related procedural pain management strategies on the risk of retinopathy in premature infants. Method: This was a prospective comparative study involving a total of 94 neonates randomized to three groups meeting the criteria for at-risk neonates. Ophthalmologic screening was performed to evaluate the outcome of three procedural pain management strategies. The intensity of pain over time during and after the screening examination was evaluated. At the same time, we also looked at the occurrence of vegetative symptoms and their influence by the chosen medication. Pain response was observed in all 94 neonates enrolled in the study. In group A, no pain treatment was given. Group B had a local anesthetic oxybuprocaine hydrochloride 0.4% introduced into both eyes immediately prior to the examination. Group C received oral clonidine. The study was conducted as a pilot project and aimed to clarify the problem so that a project with a higher proband representation could take place in the future. Consequently, we performed quantitative analysis of complete pain and vegetative functions, followed by a qualitative analysis of their internal components. Results: In our study, we identified the most considerable effects for all three groups, including NIPS (Neonatal Infant Pain Scale) responses immediately during and after the examination. The influence of vegetative functions is of a longer-term nature and increased values can be clearly demonstrated even six hours after the examination. Conclusion: The current results identify and quantify differences among all three methods of pain treatment on the level of single variables. Their internal structures, however, can be analysed only qualitatively because of the small size of the analysed sample. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://www.mdpi.com/2227-9067/9/11/1659
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