How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector

0566088 - FZÚ 2023 RIV DE eng J - Journal Article
Vaňkátová, Petra - Kubíčková, A. - Kalíková, K.
How mobile phase composition and column temperature affect enantiomer elution order of liquid crystals on amylose tris(3-chloro-5-methylphenylcarbamate) as chiral selector.
Electrophoresis. Roč. 42, 17-18 (2021), s. 1844-1852. ISSN 0173-0835. E-ISSN 1522-2683
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : enantiomer elution order * enantioseparation * liquid crystals * polysaccharide chiral stationary phase
OECD category: Analytical chemistry
Impact factor: 3.595, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/elps.202000350

A comprehensive study into the effects of mobile phase composition and column temperature on enantiomer elution order was conducted with a set of chiral rod-like liquid crystalline materials. The analytes were structurally similar and comprised variances such as length of terminal alkyl chain, presence of chlorine, number of phenyl rings, and type of chiral center. Experiments were carried out in polar organic and reversed-phase modes using amylose tris(3-chloro-5-methylphenylcarbamate) immobilized on silica gel as the chiral stationary phase. For all liquid crystals, reversal of elution order of enantiomers was observed based on type of used cosolvent and/or its content in the mobile phase, for some of the liquid crystals a temperature-induced reversal was also observed. Both linear and nonlinear dependencies of natural logarithm of enantioselectivity on temperature were found.
Permanent Link: https://hdl.handle.net/11104/0337525