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Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines
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SYSNO ASEP 0559474 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines Author(s) Kousalová, Jana (UMCH-V) RID, ORCID
Šírová, Milada (MBU-M) RID, ORCID
Kostka, Libor (UMCH-V) RID, ORCID
Šubr, Vladimír (UMCH-V) RID, ORCID
Kovářová, Jiřina (MBU-M)
Běhalová, Kateřina (MBU-M)
Studenovský, Martin (UMCH-V) RID, ORCID
Kovář, Marek (MBU-M) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDArticle number 102578 Source Title Nanomedicine: Nanotechnology, Biology and Medicine. - : Elsevier - ISSN 1549-9634
Roč. 44, August (2022)Number of pages 9 s. Language eng - English Country US - United States Keywords matrix metalloproteinases ; metastases ; actinonin Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Subject RIV - cooperation Institute of Microbiology - Oncology ; Hematology R&D Projects LTAUSA18083 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 ; MBU-M - RVO:61388971 UT WOS 000830513600002 EID SCOPUS 85133948215 DOI 10.1016/j.nano.2022.102578 Annotation The unresolved task of modern medicine is to prevent metastatic spread during and after the treatment of primary tumors. Here, the design, controlled synthesis, in-depth physicochemical and biological characteristics of a novel panel of well-defined water-soluble copolymer conjugates bearing actinonin intended for advanced drug delivery and inhibition of metastatic spread are described. Three different synthetic approaches were employed to covalently attach actinonin to the N-(2-hydroxypropyl)methacrylamide copolymers to control the release of actinonin to its pharmacologically active form. Actinonin was attached to the polymers via hydroxamate group suppressing its activity during the delivery, with the activity restored after its release in the primary tumors or metastatic foci. Importantly, developed nanosystems with favorable drug release kinetics inhibited the metastatic spread of cancer cells from primary 4T1 tumors into the lungs as well as invasion of B16F10 melanoma cells from circulation into the lungs at the dosage without any sign of toxicity. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://www.sciencedirect.com/science/article/pii/S1549963422000648?via%3Dihub
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