Analytical methods for the determination of neuroactive steroids

0546749 - ÚEB 2022 RIV CH eng J - Journal Article
Kaleta, Michal - Oklešťková, Jana - Novák, Ondřej - Strnad, Miroslav
Analytical methods for the determination of neuroactive steroids.
Biomolecules. Roč. 11, č. 4 (2021), č. článku 553. E-ISSN 2218-273X
R&D Projects: GA MŠMT(CZ) EF16_019/0000827
Institutional support: RVO:61389030
Keywords : Immunoassay * Mass spectrometry * Metabolomics * Neuroactive steroids * Steroid
OECD category: Biochemistry and molecular biology
Impact factor: 6.064, year: 2021
Method of publishing: Open access
http://doi.org/10.3390/biom11040553

Neuroactive steroids are a family of all steroid‐based compounds, of both natural and synthetic origin, which can affect the nervous system functions. Their biosynthesis occurs directly in the nervous system (so‐called neurosteroids) or in peripheral endocrine tissues (hormonal ster-oids). Steroid hormone levels may fluctuate due to physiological changes during life and various pathological conditions affecting individuals. A deeper understanding of neuroactive steroids’ pro-duction, in addition to reliable monitoring of their levels in various biological matrices, may be use-ful in the prevention, diagnosis, monitoring, and treatment of some neurodegenerative and psychi-atric diseases. The aim of this review is to highlight the most relevant methods currently available for analysis of neuroactive steroids, with an emphasis on immunoanalytical methods and gas, or liquid chromatography combined with mass spectrometry.
Permanent Link: http://hdl.handle.net/11104/0323141