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Control of oxidative stress in Jurkat cells as a model of leukemia treatment
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SYSNO ASEP 0541846 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Control of oxidative stress in Jurkat cells as a model of leukemia treatment Author(s) Pshenichnikov, S. (RU)
Omelyanchik, A. (RU)
Efremova, M. (RU)
Lunova, Mariia (FZU-D) ORCID
Gazatova, N. (RU)
Malashchenko, V. (RU)
Khaziakhmatova, O. (RU)
Litvinova, L. (RU)
Perov, N. (RU)
Panina, L. (RU)
Peddis, D. (IT)
Lunov, Oleg (FZU-D) ORCID
Rodionova, V. (RU)
Levada, K. (RU)Number of authors 14 Article number 167623 Source Title Journal of Magnetism and Magnetic Materials. - : Elsevier - ISSN 0304-8853
Roč. 523, April (2021)Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords magnetic nanoparticles ; cytotoxicity ; PBMC ; jurkat ; leukemia ; magnetic fields Subject RIV BO - Biophysics OECD category Biophysics R&D Projects EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 000605713200031 EID SCOPUS 85099211143 DOI 10.1016/j.jmmm.2020.167623 Annotation This paper describes proof-of-concept for antileukemia treatment based on the reactive oxygen species (ROS) induction supplemented with magnetic nanoparticles in the presence of moderate-intensity magnetic fields. The T-lymphoblastic leukemia cell line (Jurkat) was chosen as an in vitro model of acute lymphoblastic leukemia. The elevated ROS levels were generated by iron oxide magnetic nanoparticles. We found an enhanced cytotoxic effect of magnetic nanoparticles in the presence of a magnetic field on cancerous Jurkat cell line due to induced oxidative stress after cultivation in magnetic fields with an average strength of 0.26–0.36 T and the field spatial gradient up to 100 T/m. At the same conditions of nanoparticles intake, the viability of human peripheral blood mononuclear cells (model of healthy cells) was not inhibited. Thus, we demonstrated the feasibility of antileukemia treatment by magnetic nanoparticles controlled by a magnetic field. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2022 Electronic address https://doi.org/10.1016/j.jmmm.2020.167623
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