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Expression of Opioid Receptors in Cells of the Immune System
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SYSNO ASEP 0541562 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expression of Opioid Receptors in Cells of the Immune System Author(s) Brejchová, Jana (FGU-C) RID, ORCID
Holáň, Vladimír (UEM-P) RID
Svoboda, Petr (FGU-C) RID, ORCIDArticle number 315 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 1 (2021)Number of pages 13 s. Language eng - English Country CH - Switzerland Keywords opioid receptors ; immune cells ; stem cells ; opioid drugs ; addiction ; chronic pain Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Subject RIV - cooperation Institute of Experimental Medicine - Biochemistry R&D Projects LTAUSA18110 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-02290S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support FGU-C - RVO:67985823 ; UEM-P - RVO:68378041 UT WOS 000606078100001 EID SCOPUS 85098880723 DOI 10.3390/ijms22010315 Annotation The observation of the immunomodulatory effects of opioid drugs opened the discussion about possible mechanisms of action and led researchers to consider the presence of opioid receptors (OR) in cells of the immune system. To date, numerous studies analyzing the expression of OR subtypes in animal and human immune cells have been performed. Some of them confirmed the expression of OR at both the mRNA and protein level, while others did not detect the receptor mRNA either. Although this topic remains controversial, further studies are constantly being published. The most recent articles suggested that the expression level of OR in human peripheral blood lymphocytes could help to evaluate the success of methadone maintenance therapy in former opioid addicts, or could serve as a biomarker for chronic pain diagnosis. However, the applicability of these findings to clinical practice needs to be verified by further investigations. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2022 Electronic address https://www.mdpi.com/1422-0067/22/1/315
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