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G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
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SYSNO ASEP 0536535 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies Author(s) Carvalho, J. (PT)
Mergny, Jean-Louis (BFU-R) ORCID, RID
Salgado, G.F. (FR)
Queiroz, J.A. (PT)
Cruz, C. (PT)Number of authors 5 Source Title Trends in Molecular Medicine. - : Elsevier - ISSN 1471-4914
Roč. 26, č. 9 (2020), s. 848-861Number of pages 14 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords dna ; telomerase ; visualization ; sensitivity ; derivatives ; instability Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects EF15_003/0000477 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000567810600006 EID SCOPUS 85085353394 DOI 10.1016/j.molmed.2020.05.002 Annotation The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the notable examples of quarfloxin and AS1411, respectively. In this review, we summarize the latest achievements and breakthroughs in the use of G4 nucleic acids as both therapeutic tools ('friends', as healing anticancer drugs) and targets ('foes', within the harmful cancer cell), particularly using aptamers and quadruplex-targeted ligands, respectively. We explore the recent research on synthetic G4 ligands toward the discovery of anticancer therapeutics and their mechanism of action. Additionally, we highlight recent advances in chemical and structural biology that enable the design of specific G4 aptamers to be used as novel anticancer agents. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S1471491420301313?via%3Dihub
Number of the records: 1