Mitochondrial complex II and reactive oxygen species in disease and therapy

0535930 - BTÚ 2021 RIV GB eng J - Journal Article
Váňová Hadrava, Kateřina - Kraus, Michal - Neužil, Jiří - Rohlena, Jakub
Mitochondrial complex II and reactive oxygen species in disease and therapy.
Redox Report. Roč. 25, č. 1 (2020), s. 26-32. ISSN 1351-0002. E-ISSN 1743-2928
R&D Projects: GA ČR GA19-20553S; GA ČR(CZ) GA20-18513S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : Respiratory complex II * succinate dehydrogenase * reactive oxygen species
OECD category: Biochemistry and molecular biology
Impact factor: 4.412, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/pdf/10.1080/13510002.2020.1752002?needAccess=true&

Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases.
Permanent Link: http://hdl.handle.net/11104/0313803