N-(2-hydroxypropyl)methacrylamide-based linear, diblock, and starlike polymer drug carriers: advanced process for their simple production

Koziolová, Eva; Kostka, Libor; Kotrchová, Lenka; Šubr, Vladimír; Konefal, Rafal; Nottelet, B.; Etrych, Tomáš

doi:https://dx.doi.org/10.1021/acs.biomac.8b00973

Number of the records: 1

N-(2-hydroxypropyl)methacrylamide-based linear, diblock, and starlike polymer drug carriers: advanced process for their simple production

1.

SYSNO ASEP	0494320
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	N-(2-hydroxypropyl)methacrylamide-based linear, diblock, and starlike polymer drug carriers: advanced process for their simple production
Author(s)	Koziolová, Eva (UMCH-V)_{RID, ORCID} Kostka, Libor (UMCH-V)_{RID, ORCID} Kotrchová, Lenka (UMCH-V)_{RID, ORCID} Šubr, Vladimír (UMCH-V)_{RID, ORCID} Konefal, Rafal (UMCH-V)_{RID, ORCID} Nottelet, B. (FR) Etrych, Tomáš (UMCH-V)_{RID, ORCID}
Source Title	Biomacromolecules. - : American Chemical Society - ISSN 1525-7797 Roč. 19, č. 10 (2018), s. 4003-4013
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	HPMA ; star-like carriers ; deprotection
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	GA17-13283S GA ČR - Czech Science Foundation (CSF)
	NV16-28600A GA MZd - Ministry of Health (MZ)
	LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UMCH-V - RVO:61389013
UT WOS	000447118500010
EID SCOPUS	85053918557
DOI	10.1021/acs.biomac.8b00973
Annotation	We developed a new simplified method for the synthesis of well-defined linear, diblock, or starlike N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer drug carriers using controlled reversible addition-fragmentation chain transfer polymerization. The prepared monodispersed polymers are after the drug attachment intended for enhanced anticancer therapy. This new approach significantly reduces the number of required synthetic steps and minimizes the consumption of organic solvents during the synthesis. As a result, highly defined linear, diblock, and starlike copolymers designed for pH-triggered drug activation/release in tumor tissue were formed in sufficient amounts for further physicochemical and biological studies. Within the synthesis, we also developed a new procedure for the selective deprotection of tert-butoxycarbonyl hydrazide and amine groups on hydrophilic HPMA copolymers, including the one-pot removal of polymer end groups. We studied and described in detail the kinetics and efficacy of the deprotection reaction. We believe the simplified synthetic approach facilitates the preparation of polymer conjugates bound by the pH-sensitive hydrazone bond and their application in tumor treatment.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2019

Number of the records: 1