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Adipokinetic hormone and adenosine interfere with nematobacterial infection and locomotion in Drosophila melanogaster
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SYSNO ASEP 0489356 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Adipokinetic hormone and adenosine interfere with nematobacterial infection and locomotion in Drosophila melanogaster Author(s) Ibrahim, Emad (BC-A)
Dobeš, P. (CZ)
Kunc, M. (CZ)
Hyršl, P. (CZ)
Kodrík, Dalibor (BC-A) RID, ORCIDNumber of authors 5 Source Title Journal of Insect Physiology. - : Elsevier - ISSN 0022-1910
Roč. 107, MAY 31 (2018), s. 167-174Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords adipokinetic hormone ; adenosine ; Drosophila Subject RIV ED - Physiology OECD category Biochemistry and molecular biology R&D Projects GA17-03253S GA ČR - Czech Science Foundation (CSF) Institutional support BC-A - RVO:60077344 UT WOS 000434751100021 EID SCOPUS 85045386083 DOI 10.1016/j.jinsphys.2018.04.002 Annotation This study examined how adipokinetic hormone (AKH) and adenosine affect defense responses in Drosophila larvae infected with entomopathogenic nematodes (EPN). Three loss-of-function mutant larvae were tested: Akh1, AdoR1 (adenosine receptor), and Akh1 AdoR1. Mortality decreased in all mutants post-EPN infection compared with the control (w1118), and co-application of AKH with EPN significantly enhanced this trend. This was accompanied by elevating carbon dioxide production, a measure of metabolism. Infection elevated haemolymph lipid and carbohydrate content, but dropped level of protein after EPN infection. Furthermore, AKH application in w1118 larvae significantly increased movement distance and percentage of larval activity, but reduced velocity. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2019 Electronic address https://www.sciencedirect.com/science/article/pii/S0022191018300787
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