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The role of nitric oxide during embryonic epidermis development of Xenopus laevis
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SYSNO ASEP 0482593 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of nitric oxide during embryonic epidermis development of Xenopus laevis Author(s) Tománková, Silvie (BTO-N) RID
Abaffy, Pavel (BTO-N)
Šindelka, Radek (BTO-N) RIDNumber of authors 3 Source Title Biology Open. - : Company of Biologists - ISSN 2046-6390
Roč. 6, č. 6 (2017), s. 862-871Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords Development ; Nitric oxide ; Epidermis ; Xenopus laevis Subject RIV EB - Genetics ; Molecular Biology OECD category Developmental biology R&D Projects LK21305 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LH15074 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BTO-N - RVO:86652036 UT WOS 000403449400015 DOI 10.1242/bio.023739 Annotation Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and its downstream targets. Here we report the essential role of NO during embryonic epidermis development. Xenopus embryonic epidermis has become a useful model reflecting human epithelial tissue composition. The developing epidermis of Xenopus laevis is formed from specialized ionocytes, multi-ciliated, goblet and small secretory cells. We found that NO is mainly produced in multi-ciliated cells and ionocytes. Production of NO during early developmental stages is required for formation of multi-ciliated cells, ionocytes and small secretory cells by regulation of epidermal-specific gene expression. The data from this research indicate a novel role of NO during development, which supports recent findings of NO production in human mucociliary and epithelium development. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2018
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