Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer

Rohlenová, Kateřina; Sachaphibulkij, K.; Stursa, J.; Bezawork-Geleta, A.; Blecha, Jan; Endaya, B.; Werner, L.; Černý, Jiří; Zobalová, Renata; Goodwin, J.; Špaček, Tomáš; Pesdar, E.A.; Yan, B.; Nguyen, M.N.; Vondrusová, Magdaléna; Sobol, Margaryta; Ježek, Petr; Hozák, Pavel; Truksa, Jaroslav; Rohlena, Jakub; Dong, L.F.; Neužil, Jiří

doi:https://dx.doi.org/10.1089/ars.2016.6677

Number of the records: 1

Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer

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SYSNO ASEP	0473778
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer
Author(s)	Rohlenová, Kateřina (BTO-N)_{ORCID, RID} Sachaphibulkij, K. (AU) Stursa, J. (CZ) Bezawork-Geleta, A. (AU) Blecha, Jan (BTO-N) Endaya, B. (AU) Werner, L. (CZ) Černý, Jiří (BTO-N)_{RID, ORCID} Zobalová, Renata (BTO-N)_RID Goodwin, J. (AU) Špaček, Tomáš (FGU-C)_{RID, ORCID} Pesdar, E.A. (AU) Yan, B. (AU) Nguyen, M.N. (AU) Vondrusová, Magdaléna (BTO-N)_RID Sobol, Margaryta (UMG-J)_RID Ježek, Petr (FGU-C)_{RID, ORCID} Hozák, Pavel (UMG-J)_{RID, ORCID} Truksa, Jaroslav (BTO-N)_{RID, ORCID} Rohlena, Jakub (BTO-N)_{RID, ORCID} Dong, L.F. (AU) Neužil, Jiří (BTO-N)_RID
Source Title	Antioxidants & Redox Signaling. - : Mary Ann Liebert - ISSN 1523-0864 Roč. 26, č. 2 (2017), s. 84-103
Number of pages	20 s.
Language	eng - English
Country	US - United States
Keywords	mitochondrially targeted tamoxifen ; HER2 ; respirasome
Subject RIV	EB - Genetics ; Molecular Biology
OECD category	Biochemistry and molecular biology
Subject RIV - cooperation	Institute of Physiology - Genetics ; Molecular Biology Institute of Molecular Genetics - Genetics ; Molecular Biology
R&D Projects	GA16-12719S GA ČR - Czech Science Foundation (CSF)
	GA16-22823S GA ČR - Czech Science Foundation (CSF)
	GA13-28830S GA ČR - Czech Science Foundation (CSF)
	GA16-12816S GA ČR - Czech Science Foundation (CSF)
	TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
	FR-TI3/588 GA MPO - Ministry of Industry and Trade (MPO)
	LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BTO-N - RVO:86652036 ; FGU-C - RVO:67985823 ; UMG-J - RVO:68378050
UT WOS	000391823300003
EID SCOPUS	85008884183
DOI	10.1089/ars.2016.6677
Annotation	Aims: Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to eliminate Her2(high) disease.
Workplace	Institute of Biotechnology
Contact	Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
Year of Publishing	2018

Number of the records: 1