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From Functionalized Nanostructures Towards Engineered Macrostructures
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SYSNO ASEP 0459258 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Nanofibers as Scaffolds for Cell Transfer in Tissue Regeneration Author(s) Kubinová, Šárka (UEM-P) RID, ORCID
Zajícová, Alena (UEM-P) RID
Holáň, Vladimír (UEM-P) RID
Syková, Eva (UEM-P) RIDSource Title From Functionalized Nanostructures Towards Engineered Macrostructures. - Jindřichův Hradec : Epika, 2015 / Caruana Carmel ; Horník Jakub - ISBN 978-80-88113-20-1 Pages s. 82-98 Number of pages 17 s. Number of pages 176 Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords nanofiber ; electrospinning ; scaffold ; stem cell ; cell adhesion Subject RIV FP - Other Medical Disciplines R&D Projects LO1309 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEM-P - RVO:68378041 Annotation Nanofibrous materials that mimic the native extracellular matrix and promote the adhesion of various cells are being developed as tissue engineered scaffolds for the skin, bone, vasculature, heart, cornea, nervous system, and other tissues. As a new approach, nanofibers prepared from gelatin, PA6/12, PAN, PCL, PLA and PUR using industrial scale needleless technology have been introduced as potential cell carriers and evaluated in vitro using human mesenchymal stem cells (hMSC) and mouse limbal stem cells (mLSC). A viability assay as well as immunocytochemical examination revealed that hMSC as well as mLSC adhered, grew and proliferated on all tested nanofibers. This study confirmed that examined nanofibers have a promising potential for biomedical applications such as scaffolds for cell transfer in tissue regeneration. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2017
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