Fibrillarin from Archaea to human

0455869 - ÚMG 2016 RIV FR eng J - Journal Article
Rodriguez-Corona, U. - Sobol, Margaryta - Rodriguez-Zapata, L.C. - Hozák, Pavel - Castano, E.
Fibrillarin from Archaea to human.
Biology of the Cell. Roč. 107, č. 6 (2015), s. 159-174. ISSN 0248-4900. E-ISSN 1768-322X
Institutional support: RVO:68378050
Keywords : Cancer * Methylation * p53 * Ribosomal biogenesis * RNA processing
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.552, year: 2015

Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.
Permanent Link: http://hdl.handle.net/11104/0256471