Cardioprotective and nonprotective regimens of chronic hypoxia diversely affect the myocardial antioxidant systems

0451957 - FGÚ 2016 RIV US eng J - Journal Article
Kašparová, D. - Neckář, Jan - Dabrowská, L. - Novotný, J. - Mráz, J. - Kolář, František - Žurmanová, J.
Cardioprotective and nonprotective regimens of chronic hypoxia diversely affect the myocardial antioxidant systems.
Physiological Genomics. Roč. 47, č. 12 (2015), s. 612-620. ISSN 1094-8341. E-ISSN 1531-2267
R&D Projects: GA ČR(CZ) GAP303/12/1162; GA ČR(CZ) GA13-10267S
Institutional support: RVO:67985823
Keywords : adaptation to hypoxia * cardioprotection * ischemia-reperfusion injury * oxidative stress * antioxidant defense
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 2.615, year: 2015

It this study we investigated the relationship between myocardial tolerance to ischemia/reperfusion injury and transcription activity of major antioxidant genes, transcription factors, and oxidative stress in three different regimens of chronic hypoxia. Adult male Wistar rats were exposed to continuous normobaric hypoxia either continuously (CNH) or intermittently for 8 h/day (INH8) or 23 h/day (INH23) for 3 wk period. Whereas CNH as well as INH8 decreased infarct size, 1 h daily reoxygenation (INH23) abolished the cardioprotective effect. The majority of mRNAs of antioxidant genes related to mitochondrial antioxidant defense were upregulated in both cardioprotective regimens but not in INH23 rats. Our results suggest that the increased mitochondrial antioxidant defense plays an important role in cardioprotection afforded by chronic hypoxia
Permanent Link: http://hdl.handle.net/11104/0253019