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Considerations on electrolysis in electromembrane extraction of basic drugs
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SYSNO ASEP 0448871 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Considerations on electrolysis in electromembrane extraction of basic drugs Author(s) Šlampová, Andrea (UIACH-O) RID
Kubáň, Pavel (UIACH-O) RID, ORCID
Boček, Petr (UIACH-O) RIDNumber of authors 3 Source Title CECE 2015. 12th International Interdisciplinary Meeting on Bioanalysis. - Brno : Ústav analytické chemie AV ČR, v. v. i, 2015 / Foret František ; Křenková Jana ; Drobníková Iveta ; Klepárník Karel - ISBN 978-80-904959-3-7 Pages s. 198-201 Number of pages 4 s. Publication form Print - P Action CECE 2015. International Interdisciplinary Meeting on Bioanalysis /12./ Event date 21.09.2015-23.09.2015 VEvent location Brno Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords electrolysis ; electromembrane extraction ; basic drugs Subject RIV CB - Analytical Chemistry, Separation R&D Projects GA13-05762S GA ČR - Czech Science Foundation (CSF) Institutional support UIACH-O - RVO:68081715 UT WOS 000383860400069 Annotation Electrolysis may significantly affect composition and pH values of non-optimized acceptor solutions and have fatal consequences on quantitative EME results for weak and medium strong analytes. Acceptor solutions consisting of high concentrations of weak acids have therefore been proposed as suitable operational solutions for electromembrane extraction (EME) of selected basic drugs. 500 mM formic acid efficiently eliminated the electrolytically produced OH– ions, offered constant pH and thus long-term EME performance and was easily compatible with subsequent analytical methods. Maximum EME recoveries ranged from 66 to 89% and were constant between 40 and 80 min of EME and no back-extraction of the analytes into donor solutions was observed. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2016 Electronic address http://www.ce-ce.org/CECE2015/CECE%202015%20proceedings_full.pdf
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