Impact of endocrine disruptors on male reproductive and epigenetic parameters in a trans-generational study of mice

0445147 - BTÚ 2016 US eng A - Abstract
Pěknicová, Jana - Žatecká, Eva - Děd, Lukáš - Elzeinová, Fatima - Kubátová, Alena - Dorosh, Andriy - Margaryan, Hasmik - Dostálová, Pavla - Castillo, J. - Oliva, R.
Impact of endocrine disruptors on male reproductive and epigenetic parameters in a trans-generational study of mice.
Abstracts of the 14th International Symposium for Immunology of Reproduction “Progress in Reproductive Immunology”. Hoboken: American Journal of Reproductive Immunology, 2015 - (Mor, G.). s. 16-16. ISSN 1046-7408. E-ISSN 1600-0897.
[14th International Symposium for Immunology of Reproduction "progress in Reproductive Immunology". 22.05.2015-24.05.2015, Varna]
R&D Projects: GA ČR(CZ) GAP503/12/1834; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional research plan: CEZ:AV0Z50520701
Institutional support: RVO:86652036
Keywords : endocrine disruptors * genes * protamination * micro-RNA
Subject RIV: EB - Genetics ; Molecular Biology

The endocrine system playsan important regulatory role in human and animal bodies. This regulation may be disrupted by endocrine disruptors, which may interfere with the function of the endocrine system through diverse mechanisms.The effect of tetrabrombisphenol A (TBBPA) and vinclozolin(VIN) on reproductive parameters, sperm quality, gene expression, sperm protamination, and microRNA expression was tested in a multigenerational study. TBBPA producedinduction of apoptosis in the testes, changes in the expression of testicular genes,protamine content, and DNA integrity in the sperm with the adverse effect transmittable to the second generation. In another study, we evaluated the effect of VIN on male reproductive and epigenetic parameters in a trans-generational reproductive toxicology study in mice.Exposure to VIN led to trans- generational deregulations of microRNA expression in prenatal germ spermatic cells,which may be a cause of the observed pathological phenotypes in embryonal and adult testis in the next generations.
Permanent Link: http://hdl.handle.net/11104/0248625